Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

BACKGROUND AND PURPOSE: The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functi...

詳細記述

保存先:
書誌詳細
出版年:Br J Pharmacol
主要な著者: Norez, C, Vandebrouck, C, Bertrand, J, Noel, S, Durieu, E, Oumata, N, Galons, H, Antigny, F, Chatelier, A, Bois, P, Meijer, L, Becq, F
フォーマット: Artigo
言語:Inglês
出版事項: BlackWell Publishing Ltd 2014
主題:
Research Papers
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294108/
https://ncbi.nlm.nih.gov/pubmed/25065395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12859
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