Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

BACKGROUND AND PURPOSE: The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functi...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Norez, C, Vandebrouck, C, Bertrand, J, Noel, S, Durieu, E, Oumata, N, Galons, H, Antigny, F, Chatelier, A, Bois, P, Meijer, L, Becq, F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2014
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294108/
https://ncbi.nlm.nih.gov/pubmed/25065395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12859
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