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Unravelling druggable signalling networks that control F508del-CFTR proteostasis
Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostati...
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| 出版年: | eLife |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749566/ https://ncbi.nlm.nih.gov/pubmed/26701908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10365 |
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