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Identification of activators of ERK5 transcriptional activity by high throughput screening and the role of endothelial ERK5 in vaso-protective effects induced by statins and anti-malarial agents
Because extracellular signal-regulated kinase 5 (ERK5) inhibits endothelial inflammation and dysfunction, activating ERK5 might be a novel approach to protecting vascular endothelial cells (ECs) against various pathological conditions of the blood vessel. We have identified small molecules that prot...
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| Publié dans: | J Immunol |
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| Auteurs principaux: | , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749510/ https://ncbi.nlm.nih.gov/pubmed/25187658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400571 |
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