Identification of activators of ERK5 transcriptional activity by high throughput screening and the role of endothelial ERK5 in vaso-protective effects induced by statins and anti-malarial agents

Because extracellular signal-regulated kinase 5 (ERK5) inhibits endothelial inflammation and dysfunction, activating ERK5 might be a novel approach to protecting vascular endothelial cells (ECs) against various pathological conditions of the blood vessel. We have identified small molecules that prot...

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Veröffentlicht in:J Immunol
Hauptverfasser: Le, Nhat-Tu, Takei, Yuichiro, Izawa-Ishizawa, Yuki, Heo, Kyung-Sun, Lee, Hakjoo, Smrcka, Alan V., Miller, Benjamin L., Ko, Kyung Ae, Ture, Sara, Morrell, Craig, Fujiwara, Keigi, Akaike, Masashi, Abe, Jun-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749510/
https://ncbi.nlm.nih.gov/pubmed/25187658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400571
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