p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction

RATIONALE: Cardiomyocyte apoptosis is one of the key events in the development and progression of heart failure, and a crucial role for ICER (inducible cAMP early repressor) in this process has been previously reported. ERK5 is known to inhibit cardiac apoptosis after myocardial infarction (MI), esp...

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Bibliographische Detailangaben
Hauptverfasser: Le, Nhat-Tu, Takei, Yuichiro, Shishido, Tetsuro, Woo, Chang-Hoon, Chang, Eugene, Heo, Kyung-Sun, Lee, Hakjoo, Lu, Yan, Morrell, Craig, Oikawa, Masayoshi, McClain, Carolyn, Wang, Xin, Tournier, Cathy, Molina, Carlos A., Taunton, Jack, Yan, Chen, Fujiwara, Keigi, Patterson, Cam, Yang, Jay, Abe, Jun-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306797/
https://ncbi.nlm.nih.gov/pubmed/22267842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.254730
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