A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis

BACKGROUND: Diabetes mellitus (DM) is a major risk factor for cardiovascular mortality by increasing endothelial cell (EC) dysfunction and subsequently accelerating atherosclerosis. Extracellular-signal regulated kinase 5 (ERK5) is activated by steady laminar flow and regulates EC function by increa...

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Main Authors: Le, Nhat-Tu, Heo, Kyung-Sun, Takei, Yuichiro, Lee, Hakjoo, Woo, Chang-Hoon, Chang, Eugene, McClain, Carolyn, Hurley, Cheryl, Wang, Xin, Li, Faqian, Xu, Haodong, Morrell, Craig, Sullivan, Mark A., Cohen, Michael S., Serafimova, Iana M., Taunton, Jack, Fujiwara, Keigi, Abe, Jun-ichi
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574639/
https://ncbi.nlm.nih.gov/pubmed/23243209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.116988
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