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A clickable inhibitor reveals context-dependent autoactivation of p90 RSK
p90 ribosomal protein S6 kinases (RSKs) integrate upstream signals through two catalytic domains. Autophosphorylation of Ser386 by the regulatory C-terminal kinase domain (CTD) is thought to be essential for activation of the N-terminal kinase domain (NTD), which phosphorylates multiple downstream t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3634365/ https://ncbi.nlm.nih.gov/pubmed/17259979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio859 |
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