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Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context
Hsp90 inhibitors are currently in clinical trials for cancer therapy based on their ability to promote proteasomal degradation of oncogenic protein kinases and nuclear receptors. Results from recent studies suggest that cancer cells are more sensitive to these inhibitors than cells from healthy tiss...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2099248/ https://ncbi.nlm.nih.gov/pubmed/17643429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.06.022 |
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