Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function

Disturbed blood flow (d-flow) causes endothelial cell (EC) dysfunction, leading to atherosclerotic plaque formation. We have previously shown that d-flow increases SUMOylation of p53 and ERK5 through downregulation of sentrin/SUMO-specific protease 2 (SENP2) function; however, it is not known how SE...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Heo, Kyung-Sun, Le, Nhat-Tu, Cushman, Hannah J., Giancursio, Carolyn J., Chang, Eugene, Woo, Chang-Hoon, Sullivan, Mark A., Taunton, Jack, Yeh, Edward T.H., Fujiwara, Keigi, Abe, Jun-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362265/
https://ncbi.nlm.nih.gov/pubmed/25689261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76453
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