Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor

Growing evidence indicates a critical role of ubiquitin-proteosome system in apoptosis regulation. A cardioprotective effect of ubiquitin (Ub) ligase of the C terminus of Hsc70-interacting protein (CHIP) on myocytes has been reported. In the current study, we found that the cardioprotective effect o...

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Autores principales: Woo, Chang-Hoon, Le, Nhat-Tu, Shishido, Tetsuro, Chang, Eugene, Lee, Hakjoo, Heo, Kyung-Sun, Mickelsen, Deanne M., Lu, Yan, McClain, Carolyn, Spangenberg, Thomas, Yan, Chen, Molina, Carlos A., Yang, Jay, Patterson, Cam, Abe, Jun-ichi
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2010
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992371/
https://ncbi.nlm.nih.gov/pubmed/20724525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-162636
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