PKCζ decreases eNOS protein stability via inhibitory phosphorylation of ERK5

PKCζ has emerged as a pathologic mediator of endothelial cell dysfunction, based on its essential role in tumor necrosis factor α (TNFα)–mediated inflammation. In contrast, extracellular signal–regulated kinase 5 (ERK5) function is required for endothelial cell homeostasis as shown by activation of...

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Detalhes bibliográficos
Main Authors: Nigro, Patrizia, Abe, Jun-ichi, Woo, Chang-Hoon, Satoh, Kimio, McClain, Carolyn, O'Dell, Michael R., Lee, Hakjoo, Lim, Jae-Hyang, Li, Jian-dong, Heo, Kyung-Sun, Fujiwara, Keigi, Berk, Bradford C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173991/
https://ncbi.nlm.nih.gov/pubmed/20538799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-269134
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