O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells

Summary: Mouse embryonic stem cells (ESCs) differentiate into multiple cell types during organismal development. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from ESCs via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal...

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Main Authors: Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, Shoko Nishihara
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018-01-01
Serier:Stem Cell Reports
Fag:
O-GlcNAc
embryonic stem cell
PKCζ
MEK-ERK1/2 pathway
FGF4 signaling
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213671117305143
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