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New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth

O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies...

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Autori principali: Matjaž Weiss, Elena M. Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021-04-01
Serie:Frontiers in Chemistry
Soggetti:
O-GlcNAc
O-GlcNAc transferase
protein glycosylation
fragments growth
molecular docking
Accesso online:https://www.frontiersin.org/articles/10.3389/fchem.2021.666122/full
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