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Protonation drives the conformational switch in the multidrug transporter LmrP

Multidrug antiporters of the Major Facilitator Superfamily couple proton translocation to the extrusion of cytotoxic molecules. The conformational changes that underlie the transport cycle and the structural basis of coupling of these transporters have not been elucidated. Here we utilized extensive...

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Bibliografski detalji
Izdano u:Nat Chem Biol
Glavni autori: Masureel, Matthieu, Martens, Chloé, Stein, Richard A, Mishra, Smriti, Ruysschaert, Jean-Marie, Mchaourab, Hassane S, Govaerts, Cédric
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749020/
https://ncbi.nlm.nih.gov/pubmed/24316739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1408
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