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An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

Multidrug efflux pumps present a challenge to treatment of bacterial infections, making it vitally important to understand their mechanism of action. Here we investigated the nature of substrate binding within LmrP of L. lactis, a prototypical multidrug transporter of the major facilitator superfami...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Debruycker, Vincent, Hutchin, Andrew, Masureel, Matthieu, Ficici, Emel, Martens, Chloé, Legrand, Pierre, Stein, Richard, Mchaourab, Hassane, Faraldo-Gómez, José D., Remaut, Han, Govaerts, Cédric
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951658/
https://ncbi.nlm.nih.gov/pubmed/32719456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0464-y
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