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Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
The protein SF3B1 is a core component of the spliceosome, the large ribonucleoprotein complex responsible for pre-mRNA splicing. Interest in SF3B1 intensified when tumor exome sequencing revealed frequent specific SF3B1 mutations in a variety of neoplasia and when SF3B1 was identified as the target...
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| Veröffentlicht in: | RNA |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4748813/ https://ncbi.nlm.nih.gov/pubmed/26742993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053108.115 |
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