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Human Splicing Factor SF3a, but Not SF1, Is Essential for Pre-mRNA Splicing In Vivo

The three subunits of human splicing factor SF3a are essential for the formation of the functional 17S U2 snRNP and prespliceosome assembly in vitro. RNAi-mediated depletion indicates that each subunit is essential for viability of human cells. Knockdown of single subunits results in a general block...

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Bibliografske podrobnosti
Main Authors: Tanackovic, Goranka, Krämer, Angela
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC551499/
https://ncbi.nlm.nih.gov/pubmed/15647371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-11-1034
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