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Design, Synthesis and in Vitro Splicing Inhibition of Desmethyl and Carba-Derivatives of Herboxidiene

Herboxidiene is a potent inhibitor of spliceosomes. It exhibited excellent anticancer activity against multiple human cancer cell lines. Herein, we describe an enantioselective synthesis of a desmethyl derivative and the corresponding carba-derivatives of herboxidiene. The synthesis involved Suzuki...

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Bibliografiske detaljer
Udgivet i:Org Biomol Chem
Main Authors: Ghosh, Arun K., Lv, Kai, Ma, Nianchun, Cárdenas, Emilio L., Effenberger, Kerstin A., Jurica, Melissa S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333946/
https://ncbi.nlm.nih.gov/pubmed/27188838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00725b
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