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Design, Synthesis and in Vitro Splicing Inhibition of Desmethyl and Carba-Derivatives of Herboxidiene
Herboxidiene is a potent inhibitor of spliceosomes. It exhibited excellent anticancer activity against multiple human cancer cell lines. Herein, we describe an enantioselective synthesis of a desmethyl derivative and the corresponding carba-derivatives of herboxidiene. The synthesis involved Suzuki...
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| Veröffentlicht in: | Org Biomol Chem |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5333946/ https://ncbi.nlm.nih.gov/pubmed/27188838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00725b |
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