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Total Synthesis of GEX1Q1, Assignment of C-5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity
[Image: see text] An enantioselective total synthesis of GEX1Q1 has been accomplished in a convergent manner. The C-5 asymmetric center has now been assigned through synthesis. GEX1Q1 displayed slightly better spliceosome inhibitory activity over its C-5 epimer. The salient features of this synthesi...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American
Chemical Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051430/ https://ncbi.nlm.nih.gov/pubmed/24869489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol501345d |
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