The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems

The dual hypocretin receptor (HcrtR) antagonist almorexant (ALM) may promote sleep through selective disfacilitation of wake-promoting systems, whereas benzodiazepine receptor agonists (BzRAs) such as zolpidem (ZOL) induce sleep through general inhibition of neural activity. Previous studies have in...

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Publicat a:Neuropsychopharmacology
Autors principals: Parks, Gregory S, Warrier, Deepti R, Dittrich, Lars, Schwartz, Michael D, Palmerston, Jeremiah B, Neylan, Thomas C, Morairty, Stephen R, Kilduff, Thomas S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748439/
https://ncbi.nlm.nih.gov/pubmed/26289145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.256
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