Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy

STUDY OBJECTIVES: Humans with narcolepsy and orexin/ataxin-3 transgenic (TG) mice exhibit extensive, but incomplete, degeneration of hypo-cretin (Hcrt) neurons. Partial Hcrt cell loss also occurs in Parkinson disease and other neurologic conditions. Whether Hcrt antagonists such as almorexant (ALM)...

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Bibliografische gegevens
Hoofdauteurs: Black, Sarah Wurts, Morairty, Stephen R., Fisher, Simon P., Chen, Tsui-Ming, Warrier, Deepti R., Kilduff, Thomas S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Associated Professional Sleep Societies, LLC 2013
Onderwerpen:
Almorexant Effects on Sleep and Cataplexy in Narcolepsy Model
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571748/
https://ncbi.nlm.nih.gov/pubmed/23449602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2442
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