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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
STUDY OBJECTIVES: Humans with narcolepsy and orexin/ataxin-3 transgenic (TG) mice exhibit extensive, but incomplete, degeneration of hypo-cretin (Hcrt) neurons. Partial Hcrt cell loss also occurs in Parkinson disease and other neurologic conditions. Whether Hcrt antagonists such as almorexant (ALM)...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Associated Professional Sleep Societies, LLC
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3571748/ https://ncbi.nlm.nih.gov/pubmed/23449602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2442 |
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