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GABA(B) Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy

γ-Hydroxybutyrate (GHB) is an approved therapeutic for the excessive sleepiness and sudden loss of muscle tone (cataplexy) characteristic of narcolepsy. The mechanism of action for these therapeutic effects is hypothesized to be GABA(B) receptor dependent. We evaluated the effects of chronic adminis...

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Autori principali: Black, Sarah Wurts, Morairty, Stephen R., Chen, Tsui-Ming, Leung, Andrew K., Wisor, Jonathan P., Yamanaka, Akihiro, Kilduff, Thomas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012308/
https://ncbi.nlm.nih.gov/pubmed/24806675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0080-14.2014
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