GABA(B) Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy

γ-Hydroxybutyrate (GHB) is an approved therapeutic for the excessive sleepiness and sudden loss of muscle tone (cataplexy) characteristic of narcolepsy. The mechanism of action for these therapeutic effects is hypothesized to be GABA(B) receptor dependent. We evaluated the effects of chronic adminis...

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Bibliografiske detaljer
Main Authors: Black, Sarah Wurts, Morairty, Stephen R., Chen, Tsui-Ming, Leung, Andrew K., Wisor, Jonathan P., Yamanaka, Akihiro, Kilduff, Thomas S.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012308/
https://ncbi.nlm.nih.gov/pubmed/24806675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0080-14.2014
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