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Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

Negative affective states can increase the rewarding value of drugs of abuse and promote drug taking. Chronic cocaine exposure increases levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (KOR) that suppresses dopamine release in the nucleus accumbens (NAc) and elic...

詳細記述

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書誌詳細
出版年:Neuropsychopharmacology
主要な著者: Chartoff, Elena H, Ebner, Shayla R, Sparrow, Angela, Potter, David, Baker, Phillip M, Ragozzino, Michael E, Roitman, Mitchell F
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748424/
https://ncbi.nlm.nih.gov/pubmed/26239494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.226
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