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Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

Negative affective states can increase the rewarding value of drugs of abuse and promote drug taking. Chronic cocaine exposure increases levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (KOR) that suppresses dopamine release in the nucleus accumbens (NAc) and elic...

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Dades bibliogràfiques
Publicat a:Neuropsychopharmacology
Autors principals: Chartoff, Elena H, Ebner, Shayla R, Sparrow, Angela, Potter, David, Baker, Phillip M, Ragozzino, Michael E, Roitman, Mitchell F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748424/
https://ncbi.nlm.nih.gov/pubmed/26239494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.226
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