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Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity

Brain kappa-opioid receptors (KORs) are implicated in states of motivation and emotion. Activation of KORs negatively regulates mesolimbic dopamine (DA) neurons, and KOR agonists produce depressive-like behavioral effects. To further evaluate how KOR function affects behavior, we developed mutant mi...

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Autors principals: Van't Veer, Ashlee, Bechtholt, Anita J, Onvani, Sara, Potter, David, Wang, Yujun, Liu-Chen, Lee-Yuan, Schütz, Günther, Chartoff, Elena H, Rudolph, Uwe, Cohen, Bruce M, Carlezon, William A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682153/
https://ncbi.nlm.nih.gov/pubmed/23446450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.58
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