The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward

BACKGROUND: Increasing evidence indicates that brain kappa-opioid receptors (KORs) are involved in regulation of mood states. In animal models often used to study psychiatric illness, KOR agonists produce depressive-like effects (e.g., anhedonia) whereas KOR antagonists produce antidepressant- and a...

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Main Authors: Tomasiewicz, Hilarie C., Todtenkopf, Mark S., Chartoff, Elena H., Cohen, Bruce M., Carlezon, William A.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592608/
https://ncbi.nlm.nih.gov/pubmed/18639235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.05.029
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