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Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593 on cocaine-stimulated activity
Treatment with a kappa-opioid receptor agonist for five days decreases locomotor activity and reduces activity in response to a cocaine challenge three days later. In addition, chronic cocaine increases kappa-opioid receptor density, striatal dynorphin, and dynorphin gene expression in the striatum....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435175/ https://ncbi.nlm.nih.gov/pubmed/18395712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.02.065 |
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