ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid agonist U50488

BACKGROUND: Elevated expression of the transcription factor ΔFosB accompanies repeated exposure to drugs of abuse, particularly in brain areas associated with reward and motivation (e.g., nucleus accumbens [NAc]). The persistent effects of ΔFosB on target genes may play an important role in the deve...

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Hauptverfasser: Muschamp, John W., Nemeth, Christina L., Robison, Alfred J., Nestler, Eric J., Carlezon, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230776/
https://ncbi.nlm.nih.gov/pubmed/21962331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.08.011
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