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ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid agonist U50488
BACKGROUND: Elevated expression of the transcription factor ΔFosB accompanies repeated exposure to drugs of abuse, particularly in brain areas associated with reward and motivation (e.g., nucleus accumbens [NAc]). The persistent effects of ΔFosB on target genes may play an important role in the deve...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230776/ https://ncbi.nlm.nih.gov/pubmed/21962331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.08.011 |
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