Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

Myocardial ischemia-reperfusion (IR) injury limits the therapeutic effects of early reperfusion therapy for acute myocardial infarction (MI), in which mitochondrial permeability transition pore (mPTP) opening plays a critical role. Our aim was to determine whether poly-lactic/glycolic acid (PLGA) na...

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Pubblicato in:Sci Rep
Autori principali: Ikeda, Gentaro, Matoba, Tetsuya, Nakano, Yasuhiro, Nagaoka, Kazuhiro, Ishikita, Ayako, Nakano, Kaku, Funamoto, Daiki, Sunagawa, Kenji, Egashira, Kensuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748220/
https://ncbi.nlm.nih.gov/pubmed/26861678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20467
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