A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model

AIM: There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction (AMI), for which the effectiveness of interventional reperfusion therapy is hampered by myocardial ischemia-reperfusion (IR) injury. Pretreatment with statins before ischemia is shown to re...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nagaoka, Kazuhiro, Matoba, Tetsuya, Mao, Yajing, Nakano, Yasuhiro, Ikeda, Gentaro, Egusa, Shizuka, Tokutome, Masaki, Nagahama, Ryoji, Nakano, Kaku, Sunagawa, Kenji, Egashira, Kensuke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500569/
https://ncbi.nlm.nih.gov/pubmed/26167913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132451
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