Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

BACKGROUND: Mitochondria‐mediated cell death plays a critical role in myocardial ischemia‐reperfusion (IR) injury. We hypothesized that nanoparticle‐mediated drug delivery of mitochondrial division inhibitor 1 (Mdivi1) protects hearts from IR injury through inhibition of mitochondria outer membrane...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Ishikita, Ayako, Matoba, Tetsuya, Ikeda, Gentaro, Koga, Jun‐ichiro, Mao, Yajing, Nakano, Kaku, Takeuchi, Osamu, Sadoshima, Junichi, Egashira, Kensuke
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015412/
https://ncbi.nlm.nih.gov/pubmed/27451459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003872
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