TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes

The diabetes-associated allele in TCF7L2 increases the rate of conversion to diabetes; however, the mechanism by which this occurs remains elusive. We hypothesized that the diabetes-associated allele in this locus (rs7903146) impairs insulin secretion and that this defect would be exacerbated by acu...

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Vydáno v:Diabetes
Hlavní autoři: Shah, Meera, Varghese, Ron T., Miles, John M., Piccinini, Francesca, Dalla Man, Chiara, Cobelli, Claudio, Bailey, Kent R., Rizza, Robert A., Vella, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2016
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747457/
https://ncbi.nlm.nih.gov/pubmed/26525881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1233
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