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Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans
BACKGROUND: Metabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously associated with β cell dysfunction, would be associated with changes in these insulin pulse char...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205281/ https://ncbi.nlm.nih.gov/pubmed/32182220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136136 |
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