Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans

BACKGROUND: Metabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously associated with β cell dysfunction, would be associated with changes in these insulin pulse char...

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Vydáno v:JCI Insight
Hlavní autoři: Laurenti, Marcello C., Dalla Man, Chiara, Varghese, Ron T., Andrews, James C., Rizza, Robert A., Matveyenko, Aleksey, De Nicolao, Giuseppe, Cobelli, Claudio, Vella, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205281/
https://ncbi.nlm.nih.gov/pubmed/32182220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136136
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