Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

CONTEXT: Abnormal glucagon concentrations contribute to hyperglycemia, but the mechanisms of α-cell dysfunction in prediabetes are unclear. OBJECTIVE: We sought to determine the relative contributions of insulin secretion and action to α-cell dysfunction in nondiabetic participants across the spectr...

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Veröffentlicht in:J Clin Endocrinol Metab
Hauptverfasser: Sharma, Anu, Varghese, Ron T., Shah, Meera, Man, Chiara Dalla, Cobelli, Claudio, Rizza, Robert A., Bailey, Kent R., Vella, Adrian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2017
Schlagworte:
Clinical Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761487/
https://ncbi.nlm.nih.gov/pubmed/29126197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-01197
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