Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance

A common genetic variation in TCF7L2 is associated with type 2 diabetes. However, the mechanism by which this occurs remains elusive. In addition to affecting insulin secretion, genetic variation at the TCF7L2 locus may alter insulin action or directly modify hepatic glucose metabolism. We sought to...

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Publicat a:Diabetes
Autors principals: Varghese, Ron T., Viegas, Ivan, Barosa, Cristina, Marques, Catia, Shah, Meera, Rizza, Robert A., Jones, John G., Vella, Adrian
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2016
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806663/
https://ncbi.nlm.nih.gov/pubmed/26822092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1593
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