PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma

Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs) play key roles in the tumor immune suppressive network and tumor progression. However, precise roles of programmed death-1 (PD-1) in immunological functions of MDSCs and TAMs in head and neck squamous cell carcinoma (HN...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yu, Guang-Tao, Bu, Lin-Lin, Huang, Cong-Fa, Zhang, Wen-Feng, Chen, Wan-Jun, Gutkind, J. Silvio, Kulkarni, Ashok B., Sun, Zhi-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747210/
https://ncbi.nlm.nih.gov/pubmed/26573233
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