A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway

Our identification of dysregulation of the AKT pathway in ovarian cancer as a platinum resistance specific event led to a comprehensive analysis of in vitro, in vivo and clinical behaviour of the AKT inhibitor GSK2141795. Proteomic biomarker signatures correlating with effects of GSK2141795 were dev...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cheraghchi-Bashi, Azadeh, Parker, Christine A., Curry, Ed, Salazar, Jean-Frederic, Gungor, Hatice, Saleem, Azeem, Cunnea, Paula, Rama, Nona, Salinas, Cristian, Mills, Gordon B., Morris, Shannon R., Kumar, Rakesh, Gabra, Hani, Stronach, Euan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747185/
https://ncbi.nlm.nih.gov/pubmed/26497682
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