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Strong male bias drives germline mutation in chimpanzees

Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10(−8) per base pair per generation, with every additional year of father’s age contributing two mutations across the genome and males contributing thre...

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發表在:Science
Main Authors: Venn, Oliver, Turner, Isaac, Mathieson, Iain, de Groot, Natasja, Bontrop, Ronald, McVean, Gil
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746749/
https://ncbi.nlm.nih.gov/pubmed/24926018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.344.6189.1272
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