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Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

Prion diseases are caused by misfolding of the cellular protein PrP(C) to an infectious conformer, PrP(Sc). Intercellular PrP(Sc) transfer propagates conversion and allows infectivity to move from the periphery to the brain. However, how prions spread between cells of the central nervous system is u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Victoria, Guiliana Soraya, Arkhipenko, Alexander, Zhu, Seng, Syan, Sylvie, Zurzolo, Chiara
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746738/
https://ncbi.nlm.nih.gov/pubmed/26857744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20762
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