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Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact
Prion diseases are caused by misfolding of the cellular protein PrP(C) to an infectious conformer, PrP(Sc). Intercellular PrP(Sc) transfer propagates conversion and allows infectivity to move from the periphery to the brain. However, how prions spread between cells of the central nervous system is u...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746738/ https://ncbi.nlm.nih.gov/pubmed/26857744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20762 |
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