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Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine

The disrupted-in-schizophrenia 1 (DISC1) gene was identified as a genetic risk factor for chronic mental illnesses (CMI) such as schizophrenia, bipolar disorder and severe recurrent depression. Insoluble aggregated DISC1 variants were found in the cingular cortex of sporadic, i.e. non-genetic, CMI p...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Zhu, Seng, Abounit, Saïda, Korth, Carsten, Zurzolo, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376705/
https://ncbi.nlm.nih.gov/pubmed/28275106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160328
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