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Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine

The disrupted-in-schizophrenia 1 (DISC1) gene was identified as a genetic risk factor for chronic mental illnesses (CMI) such as schizophrenia, bipolar disorder and severe recurrent depression. Insoluble aggregated DISC1 variants were found in the cingular cortex of sporadic, i.e. non-genetic, CMI p...

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Veröffentlicht in:Open Biol
Hauptverfasser: Zhu, Seng, Abounit, Saïda, Korth, Carsten, Zurzolo, Chiara
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376705/
https://ncbi.nlm.nih.gov/pubmed/28275106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160328
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