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Comparison of the mechanisms of heme hydroxylation by heme oxygenases-1 and -2: kinetic and cryoreduction studies

The two isoforms of human heme oxygenase (HO1 and HO2) catalyze oxidative degradation of heme to biliverdin, Fe, and CO. Unlike HO1, HO2 contains two C-terminal heme regulatory motifs (HRMs) centered at Cys265 and Cys282 that act as redox switches and, in their reduced dithiolate state, bind heme (F...

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Dettagli Bibliografici
Pubblicato in:Biochemistry
Autori principali: Davydov, Roman, Fleischhacker, Angela S., Bagai, Ireena, Hoffman, Brian M., Ragsdale, Stephen W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745887/
https://ncbi.nlm.nih.gov/pubmed/26652036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00943
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