Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site

Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation to biliverdin, CO, and iron, forming an essential link in the heme metabolism network. Tight regulation of the cellular levels and catalytic activities of HO1 and HO2 is important for maintaining heme homeostasis. HO1 expression is transc...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Liu, Liu, Dumbrepatil, Arti B., Fleischhacker, Angela S., Marsh, E. Neil G., Ragsdale, Stephen W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863905/
https://ncbi.nlm.nih.gov/pubmed/33051205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014919
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