Spectroscopic Studies Reveal That the Heme Regulatory Motifs of Heme Oxygenase-2 Are Dynamically Disordered and Exhibit Redox-Dependent Interaction with Heme

[Image: see text] Heme oxygenase (HO) catalyzes a key step in heme homeostasis: the O(2)- and NADPH-cytochrome P450 reductase-dependent conversion of heme to biliverdin, Fe, and CO through a process in which the heme participates both as a prosthetic group and as a substrate. Mammals contain two iso...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Bagai, Ireena, Sarangi, Ritimukta, Fleischhacker, Angela S., Sharma, Ajay, Hoffman, Brian M., Zuiderweg, Erik R. P., Ragsdale, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423204/
https://ncbi.nlm.nih.gov/pubmed/25849895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501489r
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