Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

Mutational hotspots indicate selective pressure across a population of tumor samples, but their prevalence within and across cancer types is incompletely characterized. An approach to detect significantly mutated residues, rather than methods that identify recurrently mutated genes, may uncover new...

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Bibliographic Details
Published in:Nat Biotechnol
Main Authors: Chang, Matthew T., Asthana, Saurabh, Gao, Sizhi Paul, Lee, Byron H., Chapman, Jocelyn S., Kandoth, Cyriac, Gao, JianJiong, Socci, Nicholas D., Solit, David B., Olshen, Adam B., Schultz, Nikolaus, Taylor, Barry S.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744099/
https://ncbi.nlm.nih.gov/pubmed/26619011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3391
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