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The expanding landscape of ‘oncohistone’ mutations in human cancers
Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrate for chromatin-modifying and remodeling enzymes, are mutated in tumors including in gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in the N-termin...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6512987/ https://ncbi.nlm.nih.gov/pubmed/30894748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1038-1 |
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