ENDOTHELIAL CELL TOLERANCE TO LIPOPOLYSACCHARIDE CHALLENGE IS INDUCED BY MONOPHOSPHORYL LIPID A

Prior exposure to lipopolysaccharide (LPS) produces a reduced or “tolerant” inflammatory response to subsequent challenges with LPS, however the potent pro-inflammatory effects of LPS limit its clinical benefit. The adjuvant Monophosphoryl lipid A (MPLA) is a weak toll-like receptor 4 (TLR4) agonist...

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Pubblicato in:Clin Sci (Lond)
Autori principali: Stark, Ryan J., Choi, Hyehun, Koch, Stephen R., Fensterheim, Benjamin A., Lamb, Fred S., Sherwood, Edward R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744094/
https://ncbi.nlm.nih.gov/pubmed/26669797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20150592
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