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Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibition Reduces Endothelial Cytokine Production without Improving Permeability after Toll-like Receptor 4 (TLR4) Challenge
Sepsis represents a life-threatening event often mediated by the host’s response to pathogens such as gram-negative organisms, which release the pro-inflammatory lipopolysaccharide (LPS). Within the endothelium, the mitogen-activated protein kinase (MAPK) pathway is an important driver of endothelia...
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| Publicado no: | Transl Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8328918/ https://ncbi.nlm.nih.gov/pubmed/33857660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2021.04.001 |
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